2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl → N-(2,5-Difluoro-4-(((S)-3-methylmorpholino)methyl)phenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine
반응식
Br[C:2]1[C:15]([F:16])=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][O:10][CH2:9][C@@H:8]2[CH3:13])=[C:4]([F:17])[CH:3]=1.[F:18][C:19]1[C:20]([C:26]2[N:30]([CH:31]3[CH2:36][CH2:35][O:34][CH2:33][CH2:32]3)[C:29]([CH3:37])=[N:28][CH:27]=2)=[N:21][C:22]([NH2:25])=[N:23][CH:24]=1.CC(C)([O-])C.[K+].CC(C1C=C(C(C)C)C(C2C=CC=CC=2P(C2CCCCC2)C2CCCCC2)=C(C(C)C)C=1)C>O1CCOCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].CN(C=O)C>[F:16][C:15]1[CH:14]=[C:5]([CH2:6][N:7]2[CH2:12][CH2:11][O:10][CH2:9][C@@H:8]2[CH3:13])[C:4]([F:17])=[CH:3][C:2]=1[NH:25][C:22]1[N:21]=[C:20]([C:26]2[N:30]([CH:31]3[CH2:32][CH2:33][O:34][CH2:35][CH2:36]3)[C:29]([CH3:37])=[N:28][CH:27]=2)[C:19]([F:18])=[CH:24][N:23]=1
