HCID 57743078, 화합물 → HCID 15979331, 화합물

HRID 1924254노트

반응식

HRID 1924254 반응식
[CH:1]([C:3]1[N:7]([CH3:8])[CH:6]=[N:5][C:4]=1[C:9]#[N:10])=O.Cl.[NH2:12][CH2:13][CH:14]([C:21]1[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[C:22]=1[F:29])[CH2:15][C:16](OCC)=[O:17]>>[CH3:8][N:7]1[C:3]([CH2:1][N:12]2[CH2:13][CH:14]([C:21]3[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[C:22]=3[F:29])[CH2:15][C:16]2=[O:17])=[C:4]([C:9]#[N:10])[N:5]=[CH:6]1

참가 물질

3

반응물 2

HCID 57743078HCID 57743078, 화합물HCID 86631465HCID 86631465, 화합물

생성물 1

HCID 15979331HCID 15979331, 화합물수율 25.8%

실험 절차

1-methyl-5-{[2-oxo-4-(2,3,5-trifluorophenyl)pyrrolidin-1-yl]methyl}-1H-imidazole-4-carbonitrile 127 is prepared according to the method described in 10.1 starting from 5-formyl-1-methyl-1H-imidazole-4-carbonitrile x86 and ethyl 4-amino-3-(2,3,5-trifluorophenyl)butanoate hydrochloride x60.

출처 및 근거

ORD 기록
ord-894c930dd8c745ffa599aeab173c1c66
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178533B2

반응 노트

불러오는 중…