Dimethylformamide → 2-(Ethylthio)benzoyl chloride

HRID 1924424노트

반응식

HRID 1924424 반응식
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[CH2:7]([S:9][C:10]1C=[CH:17][CH:16]=[CH:15][C:11]=1C(O)=O)[CH3:8].CN(C=O)C>C(Cl)Cl>[CH2:7]([S:9][C:10]1[CH:11]=[CH:15][CH:16]=[CH:17][C:1]=1[C:2]([Cl:4])=[O:3])[CH3:8]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 4257582-(Ethylsulfanyl)benzoic acid

생성물 1

HCID 148531752-(Ethylthio)benzoyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Oxalyl chloride (113 μL, 1.3 mmol) was added slowly to a stirring suspension of 2-(ethylthio)benzoic acid (1-A) (182 mg, 1.0 mmol) and 3 μL DMF in methylene chloride (2 mL). After stirring for 3.5 h at room temperature, the mixture was concentrated in vacuo to give 2-(ethylthio)benzoyl chloride (1-B).

후처리

  1. concentrationthe mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-2ab74a17a2af4612954f5b2c849d1b19
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178546B2

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