Methyl 3-hydrazinylbenzoate → 3-{5-[1-(3-Methanesulfonyl-phenyl)-4-oxo-1,4-dihydro-pyridazin-3-yl]-pyrazol-1-yl}-benzoic acid methyl ester

HRID 1924548노트

반응식

HRID 1924548 반응식
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([CH3:23])(=[O:22])=[O:21])[CH:15]=2)[N:8]=1)=O.[CH3:25][O:26][C:27](=[O:36])[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([NH:34]N)[CH:29]=1>>[CH3:25][O:26][C:27](=[O:36])[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([N:34]2[C:5]([C:7]3[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]4[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([CH3:23])(=[O:22])=[O:21])[CH:15]=4)[N:8]=3)=[CH:4][CH:3]=[N:2]2)[CH:29]=1

참가 물질

3

반응물 2

HCID 11240687Methyl 3-hydrazinylbenzoateHCID 593701713-((E)-3-Dimethylamino-acryloyl)-1-(3-methansulfonyl-phenyl)-1H-pyridazin-4-one

생성물 1

HCID 593699603-{5-[1-(3-Methanesulfonyl-phenyl)-4-oxo-1,4-dihydro-pyridazin-3-yl]-pyrazol-1-yl}-benzoic acid methyl ester

실험 절차

Reaction of 3-((E)-3-dimethylamino-acryloyl)-1-(3-methansulfonyl-phenyl)-1H-pyridazin-4-one (A-7) and 3-hydrazino-benzoic acid methyl ester according to example 43 gave the desired product. MS: M=451.0 (M+H)+

출처 및 근거

ORD 기록
ord-f040d684c358462685a6b94b2861fa91
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178538B2

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