6-Fluoro-4-hydrazinoquinoline → 1-(3-Difluoromethoxy-phenyl)-3-[2-(6-fluoro-quinolin-4-yl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one
반응식
[F:1][CH:2]([F:24])[O:3][C:4]1[CH:5]=[C:6]([N:10]2[CH:15]=[CH:14][C:13](=[O:16])[C:12]([C:17](=O)/[CH:18]=[CH:19]/[N:20](C)C)=[N:11]2)[CH:7]=[CH:8][CH:9]=1.[F:25][C:26]1[CH:27]=[C:28]2[C:33](=[CH:34][CH:35]=1)[N:32]=[CH:31][CH:30]=[C:29]2[NH:36]N>>[F:1][CH:2]([F:24])[O:3][C:4]1[CH:5]=[C:6]([N:10]2[CH:15]=[CH:14][C:13](=[O:16])[C:12]([C:17]3[N:36]([C:29]4[C:28]5[C:33](=[CH:34][CH:35]=[C:26]([F:25])[CH:27]=5)[N:32]=[CH:31][CH:30]=4)[N:20]=[CH:19][CH:18]=3)=[N:11]2)[CH:7]=[CH:8][CH:9]=1참가 물질
3
실험 절차
The product was obtained starting from 1-(3-Difluoromethoxy-phenyl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one (A-10) and (6-fluoro-quinolin-4-yl)-hydrazine according to the method described for example 91. MS: M=450.1 (M+H)+
후처리
- customThe product was obtained