Water → HCID 67427009, 화합물

HRID 1925183노트

반응식

HRID 1925183 반응식
[CH2:1]([CH:3]([CH2:39][CH3:40])[CH2:4][C:5]1([C:11]([NH:13][C:14]2[C:15]([S:24]C(C3(CC(CC)CC)CCCCC3)=O)=[CH:16][C:17]3[C:22]([CH:23]=2)=[CH:21][CH:20]=[CH:19][CH:18]=3)=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:2].[OH-].[K+].O>CO.O1CCCC1>[SH:24][C:15]1[C:14]([NH:13][C:11]([C:5]2([CH2:4][CH:3]([CH2:39][CH3:40])[CH2:1][CH3:2])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]2)=[O:12])=[CH:23][C:22]2[C:17]([CH:16]=1)=[CH:18][CH:19]=[CH:20][CH:21]=2

참가 물질

6

반응물 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 86642989HCID 86642989, 화합물

생성물 1

HCID 67427009HCID 67427009, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

The crude product obtained in step A) is dissolved in a mixture of methanol and tetra-hydrofuran (1:1). Then 3.5 mol equivalents of potassium hydroxide are added at room temperature and the mixture is stirred for 1 hour. Then water is added and the mixture is washed with n-hexane. The aqueous layer is then acidified by addition of KHSO4 and extracted with chloroform. The combined extracts are washed with water and brine, dried (Na2SO4) and concentrated to obtain 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid (3-mercapto-naphthalen-2-yl)-amide.

후처리

  1. washthe mixture is washed with n-hexane
  2. additionThe aqueous layer is then acidified by addition of KHSO4
  3. extractionextracted with chloroform
  4. washThe combined extracts are washed with water and brine
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1b21271a842349d18c360f39d56ff149
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178583B2

반응 노트

불러오는 중…