6-Bromo-2-naphthalenol → 6-Bromo-1-fluoronaphthalen-2-OL
반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([OH:12])[CH:6]=[CH:5]2.C1C=CC(S(N(S(C2C=CC=CC=2)(=O)=O)[F:23])(=O)=O)=CC=1>CN(C=O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([F:23])=[C:7]([OH:12])[CH:6]=[CH:5]2참가 물질
4
실험 절차
To a solution of 6-bromo-naphthalen-2-ol (5 g, 22.4 mmol, Aldrich) in dry DMF (50 mL, Aldrich) was added N-fluorobenzene sulfonimide (21.9 g, 67.2 mmol, Aldrich). The reaction was stirred at RT for 48 h. The volatile portion was removed in vacuo and the residue was purified by silica gel chromatography (CHCl3) to give title compound as a yellow solid. MS (ESI, neg. ion) m/z: 240.0 (M−1). Mass Calc'd for C10H6BrFO: 239.96.
후처리
- customThe volatile portion was removed in vacuo
- customthe residue was purified by silica gel chromatography (CHCl3)
출처 및 근거
- ORD 기록
- ord-daa60531c2344fb39691cc2cd7b9cc5f
- 출처 데이터셋
- uspto-grants-2012_05
- 특허 번호
- US08178557B2
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