Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Methyl 4-aminooxane-4-carboxylate hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 4-Aminotetrahydro-2H-pyran-4-carboxylic acid hydrochloride | HCID 2734400 | — |
| 생성물 | Methyl 4-aminooxane-4-carboxylate hydrochloride | HCID 43811077 | — |
반응 단계
Thionyl chloride (4.02 mL, 55.1 mmol) was added in the dehydrated methanol (100 mL) solution of 4-amino-4-carboxytetrahydro-pyran monohydrochloride (5.00 g, 27.5 mmol) in an ice bath, and the mixture was heated and refluxed for 2.5 hours. The solvent was removed by distillation under reduced pressure, and the obtained crude product was washed with ethyl acetate and then dried under reduced pressure to give a colorless solid (BB04, 5.06 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08178681B2 |
| 출처 데이터셋 | uspto-grants-2012_05 |
| ORD ID | ord-7ecba03d30d747bcb75ea1f42743ff81 |
| 출처 메모 | uspto-grants-2012_05 |