Trifluoromethanesulfonic acid 6-fluoroisoquinolin-3-yl ester → Trifluoromethanesulfonic acid 5-cyano-8-fluoroisoquinolin-3-yl ester
반응식
FC1C=C2C(=CC=1)C=NC([O:12][S:13]([C:16]([F:19])([F:18])[F:17])(=O)=[O:14])=C2.[F:20][C:21]1[C:30]2[CH:29]=[N:28][C:27]([OH:31])=[CH:26][C:25]=2[C:24]([C:32]#[N:33])=[CH:23][CH:22]=1>>[C:32]([C:24]1[CH:23]=[CH:22][C:21]([F:20])=[C:30]2[C:25]=1[CH:26]=[C:27]([O:31][S:13]([C:16]([F:19])([F:18])[F:17])(=[O:14])=[O:12])[N:28]=[CH:29]2)#[N:33]참가 물질
3
실험 절차
Following the procedure for trifluoromethanesulfonic acid 6-fluoroisoquinolin-3-yl ester, using 8-fluoro-3-hydroxyisoquinoline-5-carbonitrile in place of 6-fluoroisoquinolin-3-ol, the title compound was obtained as a yellow solid. MS (ES+): m/z=321.06 [MH+]. HPLC: tR=3.58 min (ZQ2, polar—5 min).
출처 및 근거
- ORD 기록
- ord-2ca2515d5ffd481c84c81e41788584f0
- 출처 데이터셋
- uspto-grants-2012_05
- 특허 번호
- US08178668B2
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