Trifluoromethanesulfonic acid 6-fluoroisoquinolin-3-yl ester → Trifluoro-methanesulfonic acid 6-chloro-isoquinolin-3-yl ester

반응식

F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[N:7][C:6]([O:12][S:13]([C:16]([F:19])([F:18])[F:17])(=[O:15])=[O:14])=[CH:5]2.[Cl:20]C1C=C2C(=CC=1)C=NC(O)=C2>>[Cl:20][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[N:7][C:6]([O:12][S:13]([C:16]([F:19])([F:18])[F:17])(=[O:15])=[O:14])=[CH:5]2

참가 물질

반응물 2

HCID 86633147Trifluoromethanesulfonic acid 6-fluoroisoquinolin-3-yl ester

HCID 178515347HCID 178515347, 화합물

생성물 1

HCID 86633150Trifluoro-methanesulfonic acid 6-chloro-isoquinolin-3-yl ester

실험 절차

Following the procedure for trifluoromethanesulfonic acid 6-fluoroisoquinolin-3-yl ester, using 6-chloroisoquinolin-3-ol in place of 6-fluoroisoquinolin-3-ol, the title compound was obtained as a yellow solid. MS (ES+): m/z=311.69/313.63 [MH+]. HPLC: tR=3.88 min (ZQ2, polar—5 min).

출처 및 근거

ORD 기록: ord-bb056821ebcc49efb303da95b749a89c
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08178668B2

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