Potassium Carbonate → 3-(1,3-benzothiazol-2-yl)-5-(1H-indol-2-yl)pyridin-2-amine

온도

100 °C

A mixture of 3-benzothiazol-2-yl-5-bromopyridin-2-ylamine (BB7) (25 mg, 0.080 mmol), 1-Boc-indole-2-boronic acid (40 mg, 0.20 mmol) and potassium carbonate (34 mg, 0.24 mmol) in 1,4-dioxane (1.4 mL) and H2O (0.5 mL) was degassed and refilled with argon (3×) prior to the addition of Pd(dppf)Cl2 (6 mg, 0.01 mmol). The reaction mixture was degassed and refilled with argon (2×) and left to stir at 100° C. in the microwave reactor for 30 min. Then, the mixture was passed through PL-Thiol MP SPE resin and concentrated in vacuo. The residual oil was partitioned between DCM and H2O. The combined organic layers were treated with brine, dried over anhydrous Na2SO4 and concentrated in vacuo. The resulting Boc-protected intermediate was left to stir in (1:1) DCM:TFA mixture (1.0 mL) at rt for 15 min. Purification via MDP afforded the title compound as a yellow solid. MS (ES+): m/z=343.08 (100) [MH+]. HPLC: tR=4.00 min (ZQ3, polar—5 min).

1. customwas degassed
2. additionrefilled with argon (3×)
3. customThe reaction mixture was degassed
4. additionrefilled with argon (2×)
5. waitleft
6. concentrationconcentrated in vacuo
7. customThe residual oil was partitioned between DCM and H2O
8. additionThe combined organic layers were treated with brine
9. dry with materialdried over anhydrous Na2SO4
10. concentrationconcentrated in vacuo
11. waitwas left
12. stirringto stir in (1:1) DCM
13. waitTFA mixture (1.0 mL) at rt for 15 min
14. customPurification via MDP

ORD 기록

ord-2f0c4f6180ab4d188062921805e22f1d

출처 데이터셋

uspto-grants-2012_05

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08178668B2