3-Amino-2-fluorobenzotrifluoride → 2-Chloro-7-(trifluoromethyl)benzo[d]thiazole
반응식
F[C:2]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].SC1SC2C(C(F)(F)F)=CC=CC=2N=1.[Cl:27][C:28]1[S:29]C2C=CC(Cl)=CC=2N=1>>[Cl:27][C:28]1[S:29][C:2]2[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][CH:6]=[CH:5][C:3]=2[N:4]=1참가 물질
4
반응 조건
- 온도
- 90 °C
실험 절차
The title compound was prepared from 2-fluoro-3-trifluoromethylaniline via 2-mercapto-7-trifluoromethyl-1,3-benzothiazole as described for 2,5-dichloro-1,3-benzothiazole except that in the first step the reaction mixture was heated to 90° C. for 4 h.
출처 및 근거
- ORD 기록
- ord-20c89ecd561b48d1917be10f90a8064d
- 출처 데이터셋
- uspto-grants-2012_05
- 특허 번호
- US08178668B2
반응 노트
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