2-Fluoro-5-(trifluoromethyl)aniline → 2-Chloro-4-(trifluoromethyl)-1,3-benzothiazole
반응식
F[C:2]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:3]=1N.SC1SC2C=CC=C(C(F)(F)F)C=2N=1.[Cl:27][C:28]1[S:29]C2C=CC(Cl)=CC=2[N:32]=1>>[Cl:27][C:28]1[S:29][C:3]2[CH:2]=[CH:8][CH:7]=[C:6]([C:9]([F:12])([F:11])[F:10])[C:5]=2[N:32]=1참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
The title compound was prepared from 2-fluoro-5-trifluoromethylaniline via 2-mercapto-4-trifluoromethyl-1,3-benzothiazole as described for 2,5-dichloro-1,3-benzothiazole except that in the first step the reaction mixture was heated to 100° C. for 6 h.
출처 및 근거
- ORD 기록
- ord-8ff2a02ffbc94214a7f74de991f004d1
- 출처 데이터셋
- uspto-grants-2012_05
- 특허 번호
- US08178668B2
반응 노트
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