Oxycodone → Morphine Oxycodone
반응식
[CH:1]1[C:17]2[CH2:16][C@H:15]3[N:18]([CH2:20][CH2:21][C@@:7]45[C@H:14]3[CH:13]=[CH:12][C@H:10]([OH:11])[C@@H:8]4[O:9][C:5]([C:6]=25)=[C:3]([OH:4])[CH:2]=1)[CH3:19].[CH3:22][N:23]1[C@@H:40]2[CH2:41][C:28]3[CH:29]=[CH:30][C:31]([O:43][CH3:44])=[C:32]4[O:33][C@H:34]5[C:35]([CH2:37][CH2:38][C@:39]2([OH:42])[C@:26]5([C:27]=34)[CH2:25][CH2:24]1)=[O:36]>>[CH:1]1[C:17]2[CH2:16][C@H:15]3[N:18]([CH2:20][CH2:21][C@@:7]45[C@H:14]3[CH:13]=[CH:12][C@H:10]([OH:11])[C@@H:8]4[O:9][C:5]([C:6]=25)=[C:3]([OH:4])[CH:2]=1)[CH3:19].[CH3:22][N:23]1[C@@H:40]2[CH2:41][C:28]3[CH:29]=[CH:30][C:31]([O:43][CH3:44])=[C:32]4[O:33][C@H:34]5[C:35]([CH2:37][CH2:38][C@:39]2([OH:42])[C@:26]5([C:27]=34)[CH2:25][CH2:24]1)=[O:36]참가 물질
3
실험 절차
Objective The main objective was to compare the ventilatory responses to hypoxia and hypercarbia following one hour intravenous infusions of (1) morphine 15 mg, or (2) oxycodone 15 mg, or (3) morphine 10 mg+oxycodone 5 mg, or (4) oxycodone 10 mg+morphine 5 mg, or (5) morphine 7.5 mg+oxycodone 7.5 mg. Each infusion was administered over 1 h and was designated by its respective composition as M15, M10—05, M7.5—07.5, M5—010 or 015.
후처리
- waitEach infusion was administered over 1 h
출처 및 근거
- ORD 기록