HCID 20097836, 화합물 → HCID 59627195, 화합물

반응식

Br[CH2:2][C:3]1[CH:8]=[C:7]([Cl:9])[CH:6]=[C:5]([CH3:10])[C:4]=1[N+:11]([O-:13])=O.BrC[C:16]1C=CC=C(C(F)(F)F)[C:17]=1[N+:26]([O-])=O.ClC1C=C(C)C([N+]([O-])=[O:38])=C(C)C=1>>[NH2:26][CH:17]1[CH2:2][C:3]2[C:4](=[C:5]([CH3:10])[CH:6]=[C:7]([Cl:9])[CH:8]=2)[N:11]([OH:13])[C:16]1=[O:38]

참가 물질

반응물 3

HCID 20097836HCID 20097836, 화합물

HCID 59627173HCID 59627173, 화합물

HCID 59627186HCID 59627186, 화합물

생성물 1

HCID 59627195HCID 59627195, 화합물수율 50%

실험 절차

1-(Bromomethyl)-5-chloro-3-methyl-2-nitrobenzene (38) Following the procedure for the preparation of 1-(bromomethyl)-2-nitro-3-(trifluoromethyl)benzene (17) in Example 3, reaction of 5-chloro-1,3-dimethyl-2-nitrobenzene (37) provided the title compound as a solid (50%). 1H NMR (400 MHz, CDCl3) δ 2.36 (m, 3H), 4.43 (s, 2H), 7.28 (m, 1H), 7.37 (m, 1H).

출처 및 근거

ORD 기록: ord-856bd0e7fd184aada3954fbc24eb3047
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08183238B2

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