Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-bromobutanimide → Methyl 6-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]hexanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | Methyl 6-[(6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]hexanoate | HCID 25123737 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | Methyl 6-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]hexanoate | HCID 25123738 | — |
반응 단계
Put 1.75 g (5.15 mmol) 6-[(6-phenylfuro[2,3-d]pyrimidin-4-yl)amino]hexanoic acid methyl ester in 5.2 ml tetrachloromethane. At RT, add 1.054 g (5.92 mmol) N-bromosuccinimide and then heat the mixture under reflux for approx. 1 h. After cooling, concentrate by vacuum evaporation and chromatograph the residue on silica gel (solvent: cyclohexane/ethyl acetate 4:1). 0.89 g (41.2% of theor.) of the target compound is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08183246B2 |
| 출처 데이터셋 | uspto-grants-2012_05 |
| ORD ID | ord-b7872bcab40a47ccb02e4d4e23e68edd |
| 출처 메모 | uspto-grants-2012_05 |