Propionic Acid → HCID 86636877, 화합물

HRID 1927184노트

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HRID 1927184 반응식
[NH2:1][C:2]1[C:7]([NH:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:6][CH:5]=[C:4]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[N:3]=1.[C:23]([OH:27])(=[O:26])[CH2:24][CH3:25]>C(O)(C)C>[CH3:13][CH2:12][O:11][C:9]([NH:8][C:7]1[CH:6]=[CH:5][C:4]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=[N:3][C:2]=1[NH2:1])=[O:10].[C:23]([O-:27])(=[O:26])[CH2:24][CH3:25]

참가 물질

4

반응물 2

HCID 1032Propionic AcidHCID 53276Flupirtine

생성물 1

HCID 86636877HCID 86636877, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
60 °C

실험 절차

Under nitrogen atmosphere 30 g of 2-amino-3-carbethoxyamino-6-(4-fluoro-benzylamino)-pyridine and 7.5 g of propionic acid were added to 500 ml of isopropanol. The mixture was heated to 60° C. A transparent solution of flupirtine propionate was formed and was kept for 30 min at 50° C. The solution was filtered at 20° C. and crystallisation occurred while cooling the solution down to −5° C. for 12 h. The product was collected by filtration and dried at reduced pressure at room temperature for 12 h. As a result of drying 25 g white crystals of the product were obtained.

출처 및 근거

ORD 기록
ord-0a8a6cea9d06461389753bb5780152c1
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08183267B2

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