5-(Bromomethyl)-2-(trifluoromethyl)thiazole → 2-(Trifluoromethyl)-1,3-thiazole

A solution of 5-(bromomethyl)-2-(trifluoromethyl)-1,3-thiazole [prepared in accordance with U.S. Pat. No. 5,338,856] (170 mg, 069 mmol) in 5 mL of ethanol was treated sodium methylthiolate (60 mg, 0.86 mmol) at room temperature. The reaction was complete in 10 min and so the solvent was carefully removed under reduced pressure (40 mmHg) without heating. The residue was partitioned between dichloromethane and dilute hydrochloric acid, washed with saturated brine and dried over sodium sulfate. The solvent was again carefully removed under reduced pressure (40 mmHg) without heating to yield 5-[methylthio)methyl]-2-(trifluoromethyl)-1,3-thiazole (140 mg; 96%) as a pale orange liquid: 1H NMR (CDCl3) δ 7.75 (s, 1H), 3.90 (s, 2H), 2.10 (s, 3H); GCMS (FID) m/z 213 (M+).

1. customso the solvent was carefully removed under reduced pressure (40 mmHg)
2. temperaturewithout heating
3. customThe residue was partitioned between dichloromethane and dilute hydrochloric acid
4. washwashed with saturated brine
5. dry with materialdried over sodium sulfate
6. customThe solvent was again carefully removed under reduced pressure (40 mmHg)
7. temperaturewithout heating

ORD 기록

ord-9d3b74ca2f6d484a99d2d7f24e956437

출처 데이터셋

uspto-grants-2012_05

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08183270B2