Water → Methyl-5-oxo-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carboxylate

HRID 1927290노트

반응식

HRID 1927290 반응식
Cl.[NH:2]([C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=O)[NH2:3].[C:13](/[C:15](=[CH:21]\OCC)/[C:16]([O:18][CH2:19]C)=[O:17])#[N:14].C([O-])(=O)C.[Na+].O>CN(C=O)C>[CH3:19][O:18][C:16]([C:15]1[CH:21]=[N:3][N:2]2[C:4]3[C:5](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:6](=[O:8])[NH:14][C:13]=12)=[O:17]

참가 물질

6

반응물 4

HCID 962WaterHCID 104169Benzoic acid, 2-hydrazinyl-, hydrochloride (1:1)HCID 517045Sodium AcetateHCID 1715183Ethyl 2-cyano-3-ethoxyacrylate

생성물 1

HCID 136389266Methyl-5-oxo-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carboxylate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
140 °C

실험 절차

A mixture of 2-hydrazinylbenzoic acid hydrochloride (1.05 g, 5.57 mmol), (E)-ethyl 2-cyano-3-ethoxyacrylate (0.9 g, 5.32 mmol) and sodium acetate (0.457 g, 5.57 mmol) in DMF (7 mL) was heated to 140° C. for 2 h then cooled. Water (5 mL) was added and the mixture was stirred at ambient temperature for 1 h then filtered. The solid was washed with H2O, EtOH and Et2O then dried.

후처리

  1. temperaturethen cooled
  2. filtrationthen filtered
  3. washThe solid was washed with H2O, EtOH and Et2O
  4. customthen dried

출처 및 근거

ORD 기록
ord-c64623aae70b4548a6b0f3f527107b67
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08183250B2

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