Water → Methyl-5-oxo-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carboxylate

HRID 1927291노트

반응식

HRID 1927291 반응식
Cl.[NH:2]([C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=O)[NH2:3].[CH2:13]([O:15][CH:16]=[C:17]([C:20]#N)[C:18]#[N:19])C.[O-:22]CC.[Na+].O>CCO>[CH3:13][O:15][C:16]([C:17]1[CH:20]=[N:3][N:2]2[C:4]3[C:5](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:6](=[O:8])[NH:19][C:18]=12)=[O:22]

참가 물질

6

반응물 4

HCID 962WaterHCID 671522-(Ethoxymethylene)propanedinitrileHCID 104169Benzoic acid, 2-hydrazinyl-, hydrochloride (1:1)HCID 2723922Sodium ethoxide

생성물 1

HCID 136389266Methyl-5-oxo-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2-hydrazinylbenzoic acid hydrochloride (10 g, 53 mmol), 2-(ethoxymethylene)malononitrile (6.5 g, 53.2 mmol) and sodium ethoxide (4.85 g, 257 mmol) in EtOH (100 mL) was refluxed overnight then cooled to ambient temperature. Water was added and the mixture was stirred at ambient temperature for 1 h then filtered. The solid was washed with H2O, EtOH and Et2O then dried.

후처리

  1. temperaturewas refluxed overnight
  2. filtrationthen filtered
  3. washThe solid was washed with H2O, EtOH and Et2O
  4. customthen dried

출처 및 근거

ORD 기록
ord-391fcd7d3502490dbc94dbabb9bbe8a3
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08183250B2

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