Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4,4-Dimethyl-1-hydroxypentan-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | 4,4-Dimethylpent-1-ene | HCID 12984 | — |
| 반응물 | Potassium Permanganate | HCID 516875 | — |
| 반응물 | Sodium Nitrite | HCID 23668193 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 4,4-Dimethyl-1-hydroxypentan-2-one | HCID 21335642 | — |
반응 단계
To a mixture of 4,4-dimethyl-1-pentene (10 g), acetone (600 mL), water (140 mL) and acetic acid (13.5 mL) at rt was added a solution of potassium permanganate (22.3 g) in water (85 mL), followed by additional acetone (270 mL). After stirring for 40 min, sodium nitrite (11.7 g) was added, followed by dilute sulfuric acid (12%, 221 mL). The product was extracted with ether:hexanes (1:1), and the extracts were washed with saturated sodium bicarbonate and brine, dried (sodium sulfate) and concentrated. The resulting residue was purified on silica gel column (5-100% ether in hexanes) to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08183275B2 |
| 출처 데이터셋 | uspto-grants-2012_05 |
| ORD ID | ord-e415e82c687e48c1a78d0ec9848f2bdc |
| 출처 메모 | uspto-grants-2012_05 |