Sodium Sulfite → HCID 178506558, 화합물

HRID 1927684노트

반응식

HRID 1927684 반응식
[I:1][C:2]1[N:3]=[C:4]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[CH:12][CH:11]=2)[NH:5][C:6]=1I.S([O-])([O-])=O.[Na+].[Na+]>C(O)C.O>[I:1][C:2]1[N:3]=[C:4]([CH2:8][CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[CH:14][CH:15]=2)[NH:5][CH:6]=1

참가 물질

5

반응물 2

HCID 24437Sodium SulfiteHCID 686726842-[4-[2-(4,5-diiodo-1H-imidazol-2-yl)ethyl]phenyl]pyridine

생성물 1

HCID 178506558HCID 178506558, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A solution of 2-{4-[2-(4,5-diiodo-1H-imidazol-2-yl)ethyl]phenyl}pyridine (11.2 g, 22.4 mmol) and sodium sulfite (3.1 g, 24.7 mmol) in ethanol (200 mL) and water (200 mL) was heated at 100° C. for 2 days. The reaction mixture was concentrated to half its original volume and partitioned between ethyl acetate and water. The organic phase was separated and concentrated in vacuo to afford 2-{4-[2-(4-iodo-1H-imidazol-2-yl)ethyl]phenyl}pyridine, which was used without further purification.

후처리

  1. concentrationThe reaction mixture was concentrated to half its original volume
  2. custompartitioned between ethyl acetate and water
  3. customThe organic phase was separated
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-7e1f3486b3574dbf93eccbfcd40d8f67
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08183275B2

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