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2,4-bisbenzyloxy-N-butyl-5-(5-hydroxy-1,3-dihydroisoindole-2-carbonyl)-N-methylbenzamide → N-butyl-2,4-dihydroxy-5-(5-hydroxy-1,3-dihydroisoindole-2-carbonyl)-N-methylbenzamide

HRID 1927702
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인쇄 미리보기

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HRID 1927702 반응식
[H][H].C([O:10][C:11]1[CH:24]=[C:23]([O:25]CC2C=CC=CC=2)[C:22]([C:33]([N:35]2[CH2:43][C:42]3[C:37](=[CH:38][CH:39]=[C:40]([OH:44])[CH:41]=3)[CH2:36]2)=[O:34])=[CH:21][C:12]=1[C:13]([N:15]([CH2:17][CH2:18][CH2:19][CH3:20])[CH3:16])=[O:14])C1C=CC=CC=1>[Pd].C1COCC1>[CH2:17]([N:15]([CH3:16])[C:13](=[O:14])[C:12]1[CH:21]=[C:22]([C:33]([N:35]2[CH2:43][C:42]3[C:37](=[CH:38][CH:39]=[C:40]([OH:44])[CH:41]=3)[CH2:36]2)=[O:34])[C:23]([OH:25])=[CH:24][C:11]=1[OH:10])[CH2:18][CH2:19][CH3:20]
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참가 물질

5

반응물 2

HCID 596140942,4-bisbenzyloxy-N-butyl-5-(5-hydroxy-1,3-dihydroisoindole-2-carbonyl)-N-methylbenzamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 25197205N-butyl-2,4-dihydroxy-5-(5-hydroxy-1,3-dihydroisoindole-2-carbonyl)-N-methylbenzamide수율 55.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran
용매

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온도
22 °C

실험 절차

10 ml of THF, 200 mg of 5% Pd/C (50.5% of H2O) and 15.884 ml (0.708 mmol) of hydrogen are added to 200 mg (0.354 mmol) of 2,4-bisbenzyloxy-N-butyl-5-(5-hydroxy-1,3-dihydroisoindole-2-carbonyl)-N-methylbenzamide in an autoclave, and the mixture is stirred for 20 h at 22° C. Filtration, subsequent evaporation and chromatography of the residue gives 75 mg (55.1%) of N-butyl-2,4-dihydroxy-5-(5-hydroxy-1,3-dihydroisoindole-2-carbonyl)-N-methylbenzamide “A1”);

후처리

  1. filtrationFiltration, subsequent evaporation and chromatography of the residue

출처 및 근거

ORD 기록
ord-8a3c50852c65419db4dfd3b4717f837c
출처 데이터셋
uspto-grants-2012_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08183279B2

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