2-Chloro-4-(4-chloro-phenyl)-6-methyl-pyrimidine → 2-(4-Bromo-imidazol-1-yl)-4-(4-chloro-phenyl)-6-methyl-pyrimidine

HRID 1927872노트

반응식

HRID 1927872 반응식
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[CH:5]=[C:4]([CH3:15])[N:3]=1.[Br:16][C:17]1[N:18]=[CH:19][NH:20][CH:21]=1>>[Br:16][C:17]1[N:18]=[CH:19][N:20]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=3)[CH:5]=[C:4]([CH3:15])[N:3]=2)[CH:21]=1

참가 물질

3

반응물 2

HCID 202255702-Chloro-4-(4-chloro-phenyl)-6-methyl-pyrimidineHCID 178418934HCID 178418934, 화합물

생성물 1

HCID 574687362-(4-Bromo-imidazol-1-yl)-4-(4-chloro-phenyl)-6-methyl-pyrimidine

실험 절차

The title compound was prepared from 2-chloro-4-(4-chloro-phenyl)-6-methyl-pyrimidine (example A.11) (1.91 g, 8.0 mmol) and commercially available 4-bromo-imidazole (1.76 g, 12.0 mmol) according to the general procedure IVa. Obtained as a light brown solid (2.76 g, 98%). MS (ISP) 349.1 [(M+H)+]; mp 176-178° C.

출처 및 근거

ORD 기록
ord-ca66fb0132a140099f49f71a3aa65366
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08183262B2

반응 노트

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