2-Chloropyridine-4-boronic acid → HCID 60209338, 화합물

반응식

Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[C:10]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])[CH:9]=2)[CH:5]=[C:4]([C:24]([F:27])([F:26])[F:25])[N:3]=1.[Cl:28][C:29]1[CH:34]=[C:33](B(O)O)[CH:32]=[CH:31][N:30]=1>>[Cl:28][C:29]1[CH:34]=[C:33]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:16])([F:17])[F:15])=[C:10]([O:18][CH2:19][C:20]([F:21])([F:22])[F:23])[CH:9]=3)[CH:5]=[C:4]([C:24]([F:27])([F:25])[F:26])[N:3]=2)[CH:32]=[CH:31][N:30]=1

참가 물질

반응물 2

HCID 51515952-Chloropyridine-4-boronic acid

HCID 60209325HCID 60209325, 화합물

생성물 1

HCID 60209338HCID 60209338, 화합물

실험 절차

The title compound was prepared from 2-chloro-4-[3-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-6-trifluoromethyl-pyrimidine (example A.39) (0.85 g, 2.0 mmol) and commercially available 2-chloro-pyridine-4-boronic acid (0.35 g, 2.22 mmol) according to the general procedure IVb. Obtained as an off-white solid (0.71 g, 70%). MS (EI) 501.1 [(M)+]; mp 138° C.

출처 및 근거

ORD 기록: ord-c4b6cc5fbb4a4e0da9c584d6bed48e7b
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08183262B2

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