HCID 57468723, 화합물 → HCID 24760433, 화합물

반응식

[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][OH:9])=[NH:7])=[CH:4][N:3]=1.[CH3:12][C:13]1[N:18]=[C:17]([C:19](O)=O)[CH:16]=[C:15]([C:22]2[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=2)[CH:14]=1>>[CH3:19][C:17]1[N:18]=[C:13]([C:12]2[O:9][N:8]=[C:6]([C:5]3[CH:10]=[CH:11][C:2]([NH2:1])=[N:3][CH:4]=3)[N:7]=2)[CH:14]=[C:15]([C:22]2[CH:23]=[CH:24][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:27]=2)[CH:16]=1

참가 물질

반응물 2

HCID 57468723HCID 57468723, 화합물

HCID 178513347HCID 178513347, 화합물

생성물 1

HCID 24760433HCID 24760433, 화합물

실험 절차

The title compound was prepared from 6-amino-N-hydroxy-nicotinamidine (example C.3) (0.113 g, 0.53 mmol) and 6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine-2-carboxylic acid (example D.11) (0.10 g, 0.36 mmol) according to the general procedure V. Obtained as an off-white solid (0.045 g, 31%). MS (ISP) 398.1 [(M+H)+]; mp 163° C.

출처 및 근거

ORD 기록: ord-ed56a4bd38f14cabb625fc2725357b4c
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08183262B2

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