Diethanolamine → HCID 11770129, 화합물

HRID 1928537노트

반응식

HRID 1928537 반응식
[OH:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][OH:7].Br[CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[OH:1][CH2:2][CH2:3][N:4]([CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:5][CH2:6][OH:7]

참가 물질

5

반응물 3

HCID 8113DiethanolamineHCID 11430Potassium CarbonateHCID 68526Benzene, (2-bromoethoxy)-

생성물 1

HCID 11770129HCID 11770129, 화합물수율 78%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The reaction mixture of 2-(2-hydroxy-ethylamino)ethanol (32 g, 310 mmol), 1-(2-bromoethoxy)benzene (51 g, 256 mmol), and potassium carbonate (70 g, 512 mmol) in ethanol (200 mL) was refluxed overnight, concentrated, and partitioned between water and ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by column chromatography to afford the title compound (45 g, 78%).

후처리

  1. temperaturewas refluxed overnight
  2. concentrationconcentrated
  3. custompartitioned between water and ethyl acetate
  4. washThe organic layer was washed with brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated
  7. customThe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-ce6f958296a34e70b8b597c0f29faa50
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08183374B2

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