Methylamine → Aminotetrahydrocyclopenta[b]indole

HRID 1928575노트

반응식

[CH2:1]1[C:12]2[CH:4]([N:5]=[C:6]3[C:11]=2[CH:10]=[CH:9][CH:8]=[CH:7]3)[CH2:3][CH2:2]1.C[NH2:14]>>[NH2:14][CH:1]1[C:12]2[CH:4]([N:5]=[C:6]3[C:11]=2[CH:10]=[CH:9][CH:8]=[CH:7]3)[CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 6329Methylamine

HCID 66869719Tetrahydrocyclopent(b)indole

생성물 1

HCID 66933239Aminotetrahydrocyclopenta[b]indole

실험 절차

In Scheme 2, Step A, the phthalimide group of the tetrahydrocyclopenta[b]indole of formula (2) is cleaved with methylamine to provide an aminotetrahydrocyclopenta[b]indole of formula (3). Preferred conditions use a solvent such as ethanol at a temperature of about 0 to 35° C., for 3 to 24 hours. The resulting by-product is removed by making the pH alkaline and filtering the resultant precipitate. The product is isolated from the filtrate by precipitation with water and 10% NaOH.

출처 및 근거

ORD 기록: ord-adfb3cd9cc624b0c974098d072d26038
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08183388B2

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