Hydrochloride methanol → 1-[2-(Methylthio)ethyl]piperidin-4-amine dihydrochloride

반응식

C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][S:16][CH3:17])[CH2:10][CH2:9]1)(C)(C)C.[ClH:19].CO>>[ClH:19].[ClH:19].[CH3:17][S:16][CH2:15][CH2:14][N:11]1[CH2:10][CH2:9][CH:8]([NH2:7])[CH2:13][CH2:12]1

참가 물질

반응물 2

HCID 21893726Hydrochloride methanol

HCID 49817086Tert-butyl {1-[2-(methylsulfanyl)ethyl]piperidin-4-yl}carbamate

생성물 1

HCID 509443381-[2-(Methylthio)ethyl]piperidin-4-amine dihydrochloride

반응 조건

온도: 40 °C

실험 절차

[1-(2-Methylsulfanyl-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester (0.35 g, 1.0 mmol) was dissolved in HCl/Methanol (2.5M, 4 mL) and stirred for 1.5 h at 40° C. After evaporation of the solvent and drying under high vacuum, 1-(2-methylsulfanyl-ethyl)-piperidin-4-ylamine dihydrochloride was obtained as an off-white solid (0.22 g, 100%); MS: m/e=175.5 (M+H+).

후처리

customAfter evaporation of the solvent
customdrying under high vacuum

출처 및 근거

ORD 기록: ord-fa2c9de673ba48d18e2b1ed92ed4530a
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08183380B2

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