3-Methyl-4-piperidyl (3S,4S)-Pivalate → HCID 59600158, 화합물

반응식

O[CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:10][C:11]([C:13]2[NH:14][C:15]3[C:20]([CH:21]=2)=[C:19]([C:22]2[CH:23]=[N:24][C:25]([O:28][CH3:29])=[CH:26][CH:27]=2)[CH:18]=[CH:17][CH:16]=3)=[O:12])[CH2:6][CH2:5]1.[CH3:30][C@@H:31]1[C@@H:36]([O:37]C(=O)C(C)(C)C)[CH2:35][CH2:34][NH:33][CH2:32]1>>[OH:37][C@H:36]1[CH2:35][CH2:34][N:33]([CH2:2][CH2:3][N:4]2[CH2:9][CH2:8][CH:7]([NH:10][C:11]([C:13]3[NH:14][C:15]4[C:20]([CH:21]=3)=[C:19]([C:22]3[CH:23]=[N:24][C:25]([O:28][CH3:29])=[CH:26][CH:27]=3)[CH:18]=[CH:17][CH:16]=4)=[O:12])[CH2:6][CH2:5]2)[CH2:32][C@@H:31]1[CH3:30]

참가 물질

반응물 2

HCID 596002413-Methyl-4-piperidyl (3S,4S)-Pivalate

HCID 66841736HCID 66841736, 화합물

생성물 1

HCID 59600158HCID 59600158, 화합물

실험 절차

This compound is synthesized from 4-(6-Methoxy-pyridin-3-yl)-1H-indole-2-carboxylic acid [1-(2-hydroxy-ethyl)-piperidin-4-yl]-amide (184, preparation see below) and 2,2-Dimethyl-propionic acid (3S,4S)-3-methyl-piperidin-4-yl ester (17) analogously to the method described in example 150, followed by cleavage of the protecting group.

출처 및 근거

ORD 기록: ord-bc1e9b5bcf7d49e6a0c835c6828393ac
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08183366B2

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