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Triethylamine → 4-(7-Fluoro-3-methoxycarbonylmethyl-2-methyl-naphthalene-1-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester

HRID 1929578
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HRID 1929578 반응식
[CH3:1][O:2][C:3](=[O:20])[CH2:4][C:5]1[C:14]([CH3:15])=[C:13]([C:16](Cl)=[O:17])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:19])[CH:11]=2)[CH:6]=1.[C:21]([O:25][C:26]([N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)=[O:27])([CH3:24])([CH3:23])[CH3:22].C(N(CC)CC)C>ClCCl>[C:21]([O:25][C:26]([N:28]1[CH2:33][CH2:32][N:31]([C:16]([C:13]2[C:12]3[C:7](=[CH:8][CH:9]=[C:10]([F:19])[CH:11]=3)[CH:6]=[C:5]([CH2:4][C:3]([O:2][CH3:1])=[O:20])[C:14]=2[CH3:15])=[O:17])[CH2:30][CH2:29]1)=[O:27])([CH3:24])([CH3:22])[CH3:23]
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참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 143452tert-Butyl piperazine-1-carboxylateHCID 59326710(4-Chlorocarbonyl-6-fluoro-3-methyl-naphthalen-2-yl)-acetic acid methyl ester

생성물 1

HCID 593267254-(7-Fluoro-3-methoxycarbonylmethyl-2-methyl-naphthalene-1-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester수율 92.2%

시약·촉매·용매 1

HCID 6344
Dichloromethane
용매

실험 절차

To a solution of (4-chlorocarbonyl-6-fluoro-3-methyl-naphthalen-2-yl)-acetic acid methyl ester (294 mg, 1.0 mmol) and piperazine-1-carboxylic acid tert-butyl ester (279 mg, 1.5 mmol) in dichloromethane was added triethylamine (458 μL, 3.3 mmol). The resulting mixture was stirred at room temperature overnight, and concentrated in vacuo. The residue was purified by column chromatography (gradient elution with 20-40% ethyl acetate in petroleum ether) to afford 4-(7-fluoro-3-methoxycarbonylmethyl-2-methyl-naphthalene-1-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester (410 mg, 92%) as a white solid.

후처리

  1. concentrationconcentrated in vacuo
  2. customThe residue was purified by column chromatography (gradient elution with 20-40% ethyl acetate in petroleum ether)

출처 및 근거

ORD 기록
ord-d95064743bd849e8824961e2df5d96fd
출처 데이터셋
uspto-grants-2012_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08188090B2

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