홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Triethylamine → [4-(4-Ethanesulfonyl-piperazine-1-carbonyl)-6-fluoro-3-methyl-naphthalen-2-yl]-acetic acid methyl ester

HRID 1929580
노트
인쇄 미리보기

반응식

HRID 1929580 반응식
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10](=[O:32])[CH2:11][C:12]1[C:21]([CH3:22])=[C:20]([C:23]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[O:24])[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([F:31])[CH:18]=2)[CH:13]=1.[CH2:33]([S:35](Cl)(=[O:37])=[O:36])[CH3:34].C(N(CC)CC)C>ClCCl>[CH3:8][O:9][C:10](=[O:32])[CH2:11][C:12]1[C:21]([CH3:22])=[C:20]([C:23]([N:25]2[CH2:30][CH2:29][N:28]([S:35]([CH2:33][CH3:34])(=[O:37])=[O:36])[CH2:27][CH2:26]2)=[O:24])[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([F:31])[CH:18]=2)[CH:13]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 11667Ethanesulfonyl chlorideHCID 67367468[6-Fluoro-3-methyl-4-(piperazine-1-carbonyl)-naphthalen-2-yl]-acetic acid methyl ester trifluoroacetate

생성물 1

HCID 59326736[4-(4-Ethanesulfonyl-piperazine-1-carbonyl)-6-fluoro-3-methyl-naphthalen-2-yl]-acetic acid methyl ester수율 87.1%

시약·촉매·용매 1

HCID 6344
Dichloromethane
용매

실험 절차

To a solution of [6-fluoro-3-methyl-4-(piperazine-1-carbonyl)-naphthalen-2-yl]-acetic acid methyl ester trifluoroacetate (45.8 mg, 0.10 mmol) and ethanesulfonyl chloride (14 μL, 0.15 mmol) in dichloromethane was added triethylamine (306 μL, 2.2 mmol). The resulting mixture was stirred at room temperature overnight, and concentrated in vacuo. The residue was purified by column chromatography (gradient elution with 20-40% ethyl acetate in petroleum ether) to afford [4-(4-ethanesulfonyl-piperazine-1-carbonyl)-6-fluoro-3-methyl-naphthalen-2-yl]-acetic acid methyl ester (38 mg, 87%) as a white solid.

후처리

  1. concentrationconcentrated in vacuo
  2. customThe residue was purified by column chromatography (gradient elution with 20-40% ethyl acetate in petroleum ether)

출처 및 근거

ORD 기록
ord-6ce42c9a0f0a433284e6f5c6d18e8c12
출처 데이터셋
uspto-grants-2012_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08188090B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트