Malonic Acid → 3-Fluoro-4-methylcinnamic acid

HRID 1929609노트

반응식

[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[CH3:10])[CH:5]=O.C(O)(=O)[CH2:12][C:13]([OH:15])=[O:14]>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:12][C:13]([OH:15])=[O:14])[CH:7]=[CH:8][C:9]=1[CH3:10]

참가 물질

반응물 2

HCID 867Malonic Acid

HCID 27745743-Fluoro-4-methylbenzaldehyde

생성물 1

HCID 27746083-Fluoro-4-methylcinnamic acid

실험 절차

According to the previously described general procedure (GP1), Knoevenagel condensation (75° C.; 2h30) between 3-fluoro-4-methyl-benzaldehyde (10.519 g; 76.154 mmol) and malonic acid (15.056 g; 144.694 mmol) gave the product 3-(3-fluoro-4-methyl-phenyl)-acrylic acid as a colorless solid (11.860 g; 86%). LC-MS: tR=0.84 min; [M+H]+: no ionisation.

출처 및 근거

ORD 기록: ord-920f8b6c2b464ee39e9907fd04ec3c00
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08188082B2

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