3-(3,4-Dimethylphenyl)propanal → 8-[2-(3,4-Dimethyl-phenyl)-ethyl]-3-ethyl-1-iodo-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine

HRID 1929650노트

반응식

HRID 1929650 반응식
[CH2:1]([C:3]1[N:4]([CH2:9][CH2:10][NH2:11])[CH:5]=[C:6]([I:8])[N:7]=1)[CH3:2].[CH3:12][C:13]1[CH:14]=[C:15]([CH2:20][CH2:21][CH:22]=O)[CH:16]=[CH:17][C:18]=1[CH3:19]>>[CH3:12][C:13]1[CH:14]=[C:15]([CH2:20][CH2:21][CH:22]2[NH:11][CH2:10][CH2:9][N:4]3[C:3]([CH2:1][CH3:2])=[N:7][C:6]([I:8])=[C:5]23)[CH:16]=[CH:17][C:18]=1[CH3:19]

참가 물질

3

반응물 2

HCID 177837063-(3,4-Dimethylphenyl)propanalHCID 66734063HCID 66734063, 화합물

생성물 1

HCID 667339578-[2-(3,4-Dimethyl-phenyl)-ethyl]-3-ethyl-1-iodo-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine

실험 절차

According to the general procedure (GP10), the microwave-assisted Pictet-Spengler reaction (60 W; 100° C.; 8 bars; 10 min.) between 2-(2-ethyl-4-iodo-imidazol-1-yl)-ethylamine (344.6 mg; 1.300 mmol) and 3-(3,4-dimethyl-phenyl)-propionaldehyde (211.4 mg; 1.300 mmol) afforded 8-[2-(3,4-dimethyl-phenyl)-ethyl]-3-ethyl-1-iodo-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine which was Boc-protected and finally purified by HPLC.

출처 및 근거

ORD 기록
ord-048020b2ae054755abaef12ac709a94a
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188082B2

반응 노트

불러오는 중…