3-(p-Methylphenyl)propanal → 1,3-Dimethyl-8-(2-p-tolylethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine

반응식

[CH3:1][C:2]1[N:3]([CH2:8][CH2:9][NH2:10])[CH:4]=[C:5]([CH3:7])[N:6]=1.[C:11]1([CH3:21])[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][CH:19]=O)=[CH:13][CH:12]=1>>[CH3:7][C:5]1[N:6]=[C:2]([CH3:1])[N:3]2[CH2:8][CH2:9][NH:10][CH:19]([CH2:18][CH2:17][C:14]3[CH:15]=[CH:16][C:11]([CH3:21])=[CH:12][CH:13]=3)[C:4]=12

참가 물질

반응물 2

HCID 648123-(p-Methylphenyl)propanal

HCID 184607002-(2,4-Dimethyl-1H-imidazol-1-yl)ethanamine

생성물 1

HCID 667338011,3-Dimethyl-8-(2-p-tolylethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine

실험 절차

Prepared according to the previously described general procedure (GP11) by reaction of 2-(2,4-dimethyl-imidazol-1-yl)-ethylamine with 3-p-tolyl-propionaldehyde. LC-MS: tR=0.57 min.; [M+H]+=270 g/mol.

후처리

customPrepared

출처 및 근거

ORD 기록: ord-b3e1dee8599e4cc4a5e22fb66fbb8bb8
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08188082B2

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