HCID 67505124, 화합물 → 5-(4-Chloro-phenyl)-6-(2-pyridin-2-yl-ethyl)-nicotinic acid methyl ester

HRID 1929924노트

반응식

HRID 1929924 반응식
[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)[C:7]([C:17]#[C:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[N:6][CH:5]=1>[Pd].C(O)C>[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[C:8]([C:10]2[CH:11]=[CH:12][C:13]([Cl:16])=[CH:14][CH:15]=2)[C:7]([CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[N:6][CH:5]=1

참가 물질

4

반응물 1

HCID 67505124HCID 67505124, 화합물

생성물 1

HCID 675048465-(4-Chloro-phenyl)-6-(2-pyridin-2-yl-ethyl)-nicotinic acid methyl ester수율 59%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

Palladium on carbon (10% w/w, 30 mg) was added to a solution of 5-(4-Chloro-phenyl)-6-pyridin-2-ylethynyl-nicotinic acid methyl ester (0.83 mmol) in ethanol (10 ml). The reaction mixture was stirred at room temperature under an atmosphere of hydrogen for 20 hours. The reaction vessel was purged with nitrogen and catalyst was removed by filtration. The reaction mixture was concentrated in vacuo to give 5-(4-Chloro-phenyl)-6-(2-pyridin-2-yl-ethyl)-nicotinic acid methyl ester (59% yield).

후처리

  1. customThe reaction vessel was purged with nitrogen and catalyst
  2. customwas removed by filtration
  3. concentrationThe reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-b5074e6e61374db897f994d23a5dccf2
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188093B2

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