HCID 178418361, 화합물 → HCID 178501606, 화합물

HRID 19300노트

반응식

HRID 19300 반응식
[CH3:1][O:2][C:3](=[O:22])/[C:4](/[NH:11]C(OCC1C=CC=CC=1)=O)=[CH:5]/[C@H:6]1[CH2:9][C@H:8]([CH3:10])[CH2:7]1.[H][H]>[Pd].CO>[CH3:1][O:2][C:3](=[O:22])[CH:4]([NH2:11])[CH2:5][C@H:6]1[CH2:7][C@H:8]([CH3:10])[CH2:9]1

참가 물질

5

반응물 2

HCID 178418361HCID 178418361, 화합물HCID 178500468HCID 178500468, 화합물

생성물 1

HCID 178501606HCID 178501606, 화합물수율 87.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

In a Parr shaker bottle was placed (Z)-2-benzyloxycarbonylamino-3-(trans-3-methyl-cyclobutyl)-acrylic acid methyl ester (300 mg, 0.99 mmol), methanol (10 mL) and 10% palladium on activated carbon (60 mg). The mixture was placed on the Parr hydrogenator and charged with 40 psi hydrogen pressure and shaken for 1.5 h. After such time, the catalyst was filtered off through a plug of celite and the filterate concentrated in vacuo to afford 2-amino-3-(trans-3-methyl-cyclobutyl)-propionic acid methyl ester (148 mg, 87%) as a pale yellow oil.

후처리

  1. filtrationAfter such time, the catalyst was filtered off through a plug of celite
  2. concentrationthe filterate concentrated in vacuo

출처 및 근거

ORD 기록
ord-93df58aa04ce436498a50dd4958b3876
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741327B2

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