Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1930295생성일: 2026년 10월 26일
1-(4-methoxyphenyl)-N-methylmethanamine → 7-((4-methoxybenzyl)(methyl)amino)-3-(5-amino-2,4-difluorophenyl)-1-methyl-1,6-naphthyridin-2(1H)-one
https://huagongshe.com/reaction/1930295
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-(4-methoxyphenyl)-N-methylmethanamine | HCID 485407 | — |
| 반응물 | 3-(5-Amino-2,4-difluorophenyl)-7-chloro-1-methyl-1,6-naphthyridin-2(1H)-one | HCID 86620158 | — |
| 생성물 | 7-((4-methoxybenzyl)(methyl)amino)-3-(5-amino-2,4-difluorophenyl)-1-methyl-1,6-naphthyridin-2(1H)-one | HCID 69096496 | 91% |
반응 단계
3-(5-Amino-2,4-difluorophenyl)-7-chloro-1-methyl-1,6-naphthyridin-2(1H)-one (2.4 g, 7.5 mmol) and 4-methoxy-N-methylbenzyl amine (10 mL) were combined in a sealed vessel and heated to 200° C. overnight. The volatiles were removed in vacuo and the residue was purified by column chromatography to give 7-((4-methoxybenzyl)(methyl)amino)-3-(5-amino-2,4-difluorophenyl)-1-methyl-1,6-naphthyridin-2(1H)-one (3 g, 91% yield), which was used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08188113B2 |
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| 출처 데이터셋 | uspto-grants-2012_05 |
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| ORD ID | ord-dcdc3bb095ff4010ad604cf983c7add7 |
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| 출처 메모 | uspto-grants-2012_05 |
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