Ethyl 2-cyano-4-fluoro-5-nitrophenylacetate → Ethyl 2-(5-amino-2-cyano-4-fluorophenyl)acetate

HRID 1930311노트

반응식

HRID 1930311 반응식
[C:1]([C:3]1[CH:8]=[C:7]([F:9])[C:6]([N+:10]([O-])=O)=[CH:5][C:4]=1[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])#[N:2]>CO.CCOC(C)=O.[Pd]>[NH2:10][C:6]1[C:7]([F:9])=[CH:8][C:3]([C:1]#[N:2])=[C:4]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:5]=1

참가 물질

5

반응물 1

HCID 69088377Ethyl 2-cyano-4-fluoro-5-nitrophenylacetate

생성물 1

HCID 68982767Ethyl 2-(5-amino-2-cyano-4-fluorophenyl)acetate수율 81%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of ethyl 2-(2-cyano-4-fluoro-5-nitrophenyl)acetate in methanol and EtOAc (1:1, 10 mL) was added 10% Pd/C. The solution was stirred under H2 (1 arm) at RT for 3 days. The solution was filtered and evaporated to obtain ethyl 2-(5-amino-2-cyano-4-fluorophenyl)acetate (0.21 g, 81% yield).

후처리

  1. filtrationThe solution was filtered
  2. customevaporated

출처 및 근거

ORD 기록
ord-23f82806e2494fd091ad75ccf62a394e
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188113B2

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