Potassium Carbonate → 1-(2-(2-(3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-yl)ethyl)pyrrolidin-2-one

HRID 1930719노트

반응식

HRID 1930719 반응식
O=[C:2]([CH:11]1[C:16](=O)[CH2:15][CH2:14][O:13][CH2:12]1)[CH2:3][CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][C:6]1=[O:10].[CH3:18][O:19][C:20]1[CH:21]=[C:22]([NH:32][C:33]([NH2:35])=[NH:34])[CH:23]=[CH:24][C:25]=1[N:26]1[CH:30]=[C:29]([CH3:31])[N:28]=[CH:27]1.C(=O)([O-])[O-].[K+].[K+]>CCO>[CH3:18][O:19][C:20]1[CH:21]=[C:22]([NH:32][C:33]2[N:35]=[C:2]([CH2:3][CH2:4][N:5]3[CH2:9][CH2:8][CH2:7][C:6]3=[O:10])[C:11]3[CH2:12][O:13][CH2:14][CH2:15][C:16]=3[N:34]=2)[CH:23]=[CH:24][C:25]=1[N:26]1[CH:30]=[C:29]([CH3:31])[N:28]=[CH:27]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 59333778HCID 59333778, 화합물HCID 178493227HCID 178493227, 화합물

생성물 1

HCID 593337661-(2-(2-(3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-yl)ethyl)pyrrolidin-2-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1-(3-oxo-3-(4-oxotetrahydro-2H-pyran-3-yl)propyl)pyrrolidin-2-one (202 mg, 0.84 mmol), 1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)guanidine (1 equiv.) and potassium carbonate (2 equiv.) were heated to 50° C. over night in EtOH (5 mL). The crude product was extracted into DCM and solvent was evaporated. The crude product was purified by flash chromatogaphy (0-100% EtOAc in heptanes) followed by prepHPLC to afford the titled compound.

후처리

  1. extractionThe crude product was extracted into DCM and solvent
  2. customwas evaporated
  3. customThe crude product was purified by flash chromatogaphy (0-100% EtOAc in heptanes)

출처 및 근거

ORD 기록
ord-0dfd971067b4487081acab2d07b9b480
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188101B2

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