Thionyl Chloride → HCID 59333778, 화합물

HRID 1930720노트

반응식

HRID 1930720 반응식
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][C:9]([OH:11])=O.S(Cl)(Cl)=O.O=C1CCCN1CCC(Cl)=O.[O:27]1[CH2:32][CH2:31][C:30](=[O:33])[CH2:29][CH2:28]1>>[O:11]=[C:9]([CH:29]1[C:30](=[O:33])[CH2:31][CH2:32][O:27][CH2:28]1)[CH2:8][CH2:7][N:3]1[CH2:4][CH2:5][CH2:6][C:2]1=[O:1]

참가 물질

5

반응물 4

HCID 24386Thionyl ChlorideHCID 121599Tetrahydro-4H-pyran-4-oneHCID 31466882-Oxo-1-pyrrolidinepropanoic acidHCID 12843799HCID 12843799, 화합물2회

생성물 1

HCID 59333778HCID 59333778, 화합물수율 25.6%

실험 절차

3-(2-Oxopyrrolidin-1-yl)propanoic acid (519 mg, 3.3 mmol) was heated to reflux in thionyl chloride (0.365 ml, 5.00 mmol) for 30 min. The excess of thionyl chloride was evaporated and the product, (3-(2-oxopyrrolidin-1-yl)propanoyl chloride (3.3 mmol)) used as such in the next step. 1-(3-oxo-3-(4-oxotetrahydro-2H-pyran-3-yl)propyl)pyrrolidin-2-one (202 mg, 15%) was synthesised from dihydro-2H-pyran-4(3H)-one (0.462 ml, 5.00 mmol) and 3-(2-oxopyrrolidin-1-yl)propanoyl chloride (3.3 mmol) by the general procedure for the preparation of diketones.

후처리

  1. customThe excess of thionyl chloride was evaporated

출처 및 근거

ORD 기록
ord-e4ca1242ece74fbbbd97f1b2c853f409
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188101B2

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