Stannane, tributyl(1-ethoxyethenyl)- → 1-(6-Trifluoromethyl-2,3-dihydro-1H-isoindol-5-yl)-ethanone

반응식

C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:18]([F:21])([F:20])[F:19])=[C:13](I)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[CH2:22]([O:24]C([Sn](CCCC)(CCCC)CCCC)=C)[CH3:23]>>[F:21][C:18]([F:19])([F:20])[C:12]1[CH:11]=[C:10]2[C:15]([CH2:16][NH:8][CH2:9]2)=[CH:14][C:13]=1[C:22](=[O:24])[CH3:23]

참가 물질

반응물 2

HCID 619414Stannane, tributyl(1-ethoxyethenyl)-

HCID 57753490HCID 57753490, 화합물

생성물 1

HCID 577532811-(6-Trifluoromethyl-2,3-dihydro-1H-isoindol-5-yl)-ethanone

실험 절차

Prepared in analogy to Example A47 from 5-iodo-6-trifluoromethyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A35(d)) and 1-ethoxyvinyltributylstannane. White solid. MS (m/e): 230.3 ([M+H]+, 100%).

출처 및 근거

ORD 기록: ord-6da8c10a1ed04f42b34439988812fc48
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08188139B2

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