Trifluoroacetic acid → 5-Cyclopropyl-6-(tetrahydro-pyran-4-yl)-2,3-dihydro-1H-isoindole trifluoro-acetate

HRID 1930908노트

반응식

HRID 1930908 반응식
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([CH:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[C:13]([CH:17]3[CH2:19][CH2:18]3)[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]>>[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29].[CH:17]1([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][C:12]=2[CH:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[CH2:9][NH:8][CH2:16]3)[CH2:18][CH2:19]1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 577533055-Cyclopropyl-6-(tetrahydro-pyran-4-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl Ester

생성물 1

HCID 688258565-Cyclopropyl-6-(tetrahydro-pyran-4-yl)-2,3-dihydro-1H-isoindole trifluoro-acetate

실험 절차

Prepared in analogy to Example A2(c) from 5-cyclopropyl-6-(tetrahydro-pyran-4-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Brown solid. MS (m/e): 244.4 ([M+H]+, 100%).

출처 및 근거

ORD 기록
ord-4d57c1e15f504caa9cab4711ab779305
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188139B2

반응 노트

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