2-benzyl-5-((2S,6R)-2,6-dimethyl-3,6-dihydro-2H-pyran-4-yl)-2,3-dihydro-1H-isoindole → 5-((2S,6R)-2,6-Dimethyl-tetrahydro-pyran-4-yl)-2,3-dihydro-1H-isoindole

HRID 1930930노트

반응식

HRID 1930930 반응식
C([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]3[CH2:18][C@H:19]([CH3:24])[O:20][C@H:21]([CH3:23])[CH:22]=3)[CH:14]=2)[CH2:9]1)C1C=CC=CC=1.[H][H]>>[CH3:23][C@H:21]1[CH2:22][CH:17]([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][NH:8][CH2:16]3)[CH2:18][C@@H:19]([CH3:24])[O:20]1

참가 물질

3

반응물 2

HCID 577537092-benzyl-5-((2S,6R)-2,6-dimethyl-3,6-dihydro-2H-pyran-4-yl)-2,3-dihydro-1H-isoindoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 577534495-((2S,6R)-2,6-Dimethyl-tetrahydro-pyran-4-yl)-2,3-dihydro-1H-isoindole

실험 절차

Prepared in analogy to Example A62(c) from 2-benzyl-5-((2S,6R)-2,6-dimethyl-3,6-dihydro-2H-pyran-4-yl)-2,3-dihydro-1H-isoindole and hydrogen. Brown oil. MS (m/e): 232.1 ([M+H]+, 100%).

출처 및 근거

ORD 기록
ord-a26c5725a274422d8ac9a8020cc2e66e
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188139B2

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