Trifluoroacetic acid → 5-(2,2,2-Trifluoro-ethoxy)-2,3-dihydro-1H-isoindole trifluoroacetate

반응식

C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:17][CH2:18][C:19]([F:22])([F:21])[F:20])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>>[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26].[F:22][C:19]([F:20])([F:21])[CH2:18][O:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:16]2

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 577537125-(2,2,2-Trifluoro-ethoxy)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

생성물 1

HCID 866070095-(2,2,2-Trifluoro-ethoxy)-2,3-dihydro-1H-isoindole trifluoroacetate

실험 절차

Prepared in analogy to Example A2(c) from 5-(2,2,2-trifluoro-ethoxy)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and trifluoroacetic acid. Brown oil. MS (m/e): 218.4 ([M+H]+, 100%).

출처 및 근거

ORD 기록: ord-265ef781b7dc4654a54c09624d023edb
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08188139B2

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