N-Hydroxy-3-(1-phenylmethanesulfonyl-1H-pyrrol-3-yl)-acrylamide → HCID 11348242, 화합물

HRID 1931037노트

반응식

HRID 1931037 반응식
ONC(=O)C=CC1C=CN(S(CC2C=CC=CC=2)(=O)=O)C=1.[CH3:22][N:23]([CH3:50])[C:24]1[CH:29]=[CH:28][C:27]([S:30]([N:33]2[CH:37]=[CH:36][C:35](/[CH:38]=[CH:39]/[C:40]([NH:42][O:43]C3CCCCO3)=[O:41])=[CH:34]2)(=[O:32])=[O:31])=[CH:26][CH:25]=1>CO.O>[CH3:50][N:23]([CH3:22])[C:24]1[CH:25]=[CH:26][C:27]([S:30]([N:33]2[CH:37]=[CH:36][C:35](/[CH:38]=[CH:39]/[C:40]([NH:42][OH:43])=[O:41])=[CH:34]2)(=[O:31])=[O:32])=[CH:28][CH:29]=1

참가 물질

4

반응물 2

HCID 73069393N-Hydroxy-3-(1-phenylmethanesulfonyl-1H-pyrrol-3-yl)-acrylamideHCID 86613976HCID 86613976, 화합물2회

생성물 1

HCID 11348242HCID 11348242, 화합물

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

실험 절차

The method used for preparation of this compound is analogous to the method described for compound 2. Starting materials: (E)-3-[1-(4-dimethylamino-benzene sulfonyl)-1H-pyrrol-3-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide (compound A4) (0.200 g), methanol/water 3/2 (50 ml), amberlyst IR15 (0.402 g). Reaction conditions: room temperature, 34 hours.

후처리

  1. customThe method used for preparation of this compound
  2. customReaction conditions
  3. customroom temperature, 34 hours

출처 및 근거

ORD 기록
ord-b545ff5f56884dafbc9727a58914970d
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188138B2

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