Trifluoroacetic acid → [6-(2-Fluoro-phenyl)-pyridazin-3-yloxy]-acetic acid

HRID 1931381노트

반응식

HRID 1931381 반응식
C([O:5][C:6](=[O:22])[CH2:7][O:8][C:9]1[N:10]=[N:11][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[CH:13][CH:14]=1)(C)(C)C.C(O)(C(F)(F)F)=O>>[F:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:12]1[N:11]=[N:10][C:9]([O:8][CH2:7][C:6]([OH:22])=[O:5])=[CH:14][CH:13]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 68537532[6-(2-Fluoro-phenyl)-pyridazin-3-yloxy]-acetic acid tert-butyl ester

생성물 1

HCID 68537815[6-(2-Fluoro-phenyl)-pyridazin-3-yloxy]-acetic acid

실험 절차

To the crude [6-(2-fluoro-phenyl)-pyridazin-3-yloxy]-acetic acid tert -butyl ester obtained in step (b) 5 ml of 90% aqueous TFA were added, and the mixture was allowed to stand at room temperature overnight. After evaporation, a sodium hydrogencarbonate solution was added, and the solution extracted with ethyl acetate. The aqueous phase was acidified to pH=4 and extracted with ethyl acetate. The combined extracts were dried and evaporated. Yield: 20 mg.

후처리

  1. customAfter evaporation
  2. additiona sodium hydrogencarbonate solution was added
  3. extractionthe solution extracted with ethyl acetate
  4. extractionextracted with ethyl acetate
  5. customThe combined extracts were dried
  6. customevaporated

출처 및 근거

ORD 기록
ord-1d17238563f544ae8dc5ec20c71587ec
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188291B2

반응 노트

불러오는 중…