Trifluoroacetic acid → (6-Bromo-pyridazin-3-yloxy)-acetic acid

HRID 1931384노트

반응식

HRID 1931384 반응식
C([O:5][C:6](=[O:16])[CH2:7][O:8][C:9]1[N:10]=[N:11][C:12]([Br:15])=[CH:13][CH:14]=1)(C)(C)C.C(O)(C(F)(F)F)=O>>[Br:15][C:12]1[N:11]=[N:10][C:9]([O:8][CH2:7][C:6]([OH:16])=[O:5])=[CH:14][CH:13]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 86638119(6-Bromo-pyridazin-3-yloxy)-acetic acid tert-butyl ester

생성물 1

HCID 86638120(6-Bromo-pyridazin-3-yloxy)-acetic acid

실험 절차

To the crude (6-bromo-pyridazin-3-yloxy)-acetic acid tert-butyl ester obtained in step (a) 5 ml of 90% aqueous TFA were added, and the mixture was allowed to stand at room temperature for 3 h. After evaporation, a sodium hydrogencarbonate solution was added, and the solution extracted with ethyl acetate. The aqueous phase was acidified to pH=4 and extracted with ethyl acetate. The combined extracts were dried and evaporated. Yield: 147 mg.

후처리

  1. customAfter evaporation
  2. additiona sodium hydrogencarbonate solution was added
  3. extractionthe solution extracted with ethyl acetate
  4. extractionextracted with ethyl acetate
  5. customThe combined extracts were dried
  6. customevaporated

출처 및 근거

ORD 기록
ord-f0787ce48fa44885af4b06184557e744
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188291B2

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