Triethylamine → HCID 68537700, 화합물

HRID 1931407노트

반응식

HRID 1931407 반응식
[CH2:1]([O:3][C:4](=[O:13])[CH2:5][C:6]([CH3:12])([CH3:11])[C:7](=O)[CH2:8]Br)[CH3:2].[F:14][C:15]([F:26])([F:25])[C:16]1[CH:24]=[CH:23][C:19]([C:20]([NH2:22])=[S:21])=[CH:18][CH:17]=1.C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:13])[CH2:5][C:6]([CH3:12])([C:7]1[N:22]=[C:20]([C:19]2[CH:18]=[CH:17][C:16]([C:15]([F:25])([F:14])[F:26])=[CH:24][CH:23]=2)[S:21][CH:8]=1)[CH3:11])[CH3:2]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 2724583Ethyl 5-bromo-3,3-dimethyl-4-oxopentanoateHCID 27348234-(Trifluoromethyl)thiobenzamide

생성물 1

HCID 68537700HCID 68537700, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

500 mg (1.99 mmol) of 5-bromo-3,3-dimethyl-4-oxo-pentanoic acid ethyl ester, 408.6 mg (1.99 mmol) of 4-trifluoromethyl-thiobenzamide and 403 mg (3.98 mmol) of triethylamine in 10 ml of toluene were stirred at 80° C. for 2 h. After evaporation, water and dichloromethane were added, the organic phase was separated, washed with water, dried, and evaporated. The product was purified by chromatography (silica gel, n-heptane/ethyl acetate 8:1). Yield: 498.5 mg.

후처리

  1. customAfter evaporation, water and dichloromethane
  2. additionwere added
  3. customthe organic phase was separated
  4. washwashed with water
  5. customdried
  6. customevaporated
  7. customThe product was purified by chromatography (silica gel, n-heptane/ethyl acetate 8:1)

출처 및 근거

ORD 기록
ord-9c784b38cb46447dbea445840834b450
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188291B2

반응 노트

불러오는 중…