Trifluoroacetic acid → HCID 68536712, 화합물

HRID 1931411노트

반응식

C([O:5][C:6](=[O:21])[CH2:7][O:8][C:9]1[S:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[N:13]=1)(C)(C)C.[C:22]([OH:28])([C:24]([F:27])([F:26])[F:25])=[O:23]>>[F:25][C:24]([F:27])([F:26])[C:22]([OH:28])=[O:23].[F:20][C:17]1[CH:16]=[CH:15][C:14]([C:12]2[N:13]=[C:9]([O:8][CH2:7][C:6]([OH:21])=[O:5])[S:10][CH:11]=2)=[CH:19][CH:18]=1

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 68539591HCID 68539591, 화합물2회

생성물 1

HCID 68536712HCID 68536712, 화합물

실험 절차

The mixture from step (b) containing crude [4-(4-fluoro-phenyl)-thiazol-2-yloxy]-acetic acid tert-butyl ester in 5 ml of 90% aqueous TFA was allowed to stand at room temperature for 2 h. After evaporation, the crude product (815 mg) was used in the subsequent step.

후처리

customAfter evaporation

출처 및 근거

ORD 기록: ord-47a03fe5f79246a6917c43cc5ca39ff2
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08188291B2

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